Genesis 3:24

3:24 When he drove the man out, he placed on the eastern side of the orchard in Eden angelic sentries who used the flame of a whirling sword to guard the way to the tree of life.

Genesis 13:11

13:11 Lot chose for himself the whole region of the Jordan and traveled toward the east.

So the relatives separated from each other.

Genesis 28:14

28:14 Your descendants will be like the dust of the earth, and you will spread out to the west, east, north, and south. All the families of the earth will pronounce blessings on one another using your name and that of your descendants.