The relationship of chapters 1-5 to Isaiah's call in chapter 6 is problematic. Do the first five chapters describe the prophet's ministry before he received his call--is the order chronological--or do they constitute an introduction to the anthology of prophecies that follow Isaiah's call--is the order literary? The commentators take both views. My preference is to view these prophecies not necessarily as the first ones Isaiah delivered in his ministry but as those he placed here to form an introduction to his whole book. They present in a succinct way the problem that the rest of the book solves. Isaiah's call (ch. 6) is the most concise statement of the solution, and the chapters after that one spell it out in more detail. Probably Isaiah, or whoever arranged these prophecies in their final form, put these prophecies here to set before the reader the situation facing Israel that Isaiah addressed in the rest of the book.
Most serious students of Isaiah have believed that the record of Isaiah's call in this chapter occurred before he wrote any of the prophecies in this book. The title "holy one of Israel,"Isaiah's trademark name for God, connects with his call, and he used that title for God throughout the book. Likewise the prophet's emphases on glory, majesty, and righteousness are strong in chapter 6, and they appear throughout the rest of the book. As already mentioned, the three messages in chapters 1-5 provide a perfect introduction to the rest of the book, and it was probably for this reason that these chapters were arranged in the text before chapter 6.
"6:1-13 is not simply his justification for being a prophet but is more particularly the heart of his answer to the problems raised by his preface [chs. 1-5]. It speaks of the triumph of grace."68
Also, chapter 6 provides a good transition into the prophecies that appear next, in chapters 7-39 and, particularly, in chapters 7-12. It shows how the sinful nation could become the Lord's servant (a kingdom of priests), namely, by really seeing Yahweh and allowing Him to deal with her sin, as Isaiah did. It also explains the hardness of Israel that follows; she had not seen God and had not responded appropriately to Him, as Isaiah did.69
This long section of the book deals with Israel's major decision in Isaiah's day. Would she trust in Yahweh or in other nations? The decision was a matter of faith; who is more trustworthy, God or strong people? God promised that trust in the nations would result in destruction (ch. 34) but trust in Him would bring abundance (ch. 35). Israel's decision would also determine whether she had a message for the nations or not and whether she would fulfill her mission to the nations or not. This decision is, of course, one that the people of God of all ages continually face.
This part of Isaiah picks up a theme from chapters 1-39 and develops it further. That theme is God's faithfulness to His promises to give His people a glorious future after He disciplined them for their unfaithfulness. The Lord did not have to make these promises, but He did so in grace. Israel would have a glorious future, not because of but in spite of herself.
The last major section of Isaiah deals with the necessity of living out the righteousness of God (cf. Rom. 12-16). These chapters emphasize what the characteristics of the servants of the Lord should be. Again, the focus is on Israel primarily but not exclusively. All God's people are in view, though God's will for Israel and His promises to Israel were Isaiah's chief concerns.633
"These chapters are about the internalization of the law by means of an intimate relationship with the God who alone can enable people to live holy lives."634
This section also clarifies the relationship between works and grace, both of which Isaiah spoke of as essential in his earlier chapters.
The structure of this section is as follows.635
AForeign worshipers 56:1-8
BEthical righteousness 56:9-59:15a
CThe divine warrior 59:15b-21
DEschatological hope chs. 60-62
C'The divine warrior 63:1-6
B'Ethical righteousness 63:7-66:17
A'Foreign worshipers 66:18-24