The apostle brought together words and ideas from his earlier epistles as well as from this one in this doxology.
16:25 The apostle was confident that God could do for his readers what they needed (cf. 1:11; Eph. 3:20). The gospel is God's chief tool to that end. "My gospel"identifies the one that Paul had preached widely and had expounded in this epistle. The "preaching of Jesus Christ"is another name for the gospel that stresses its subject, Jesus Christ. Proclamation follows revelation. The gospel had been hidden in eternity past until God revealed it first in the Old Testament and then fully in the New.
16:26 Even though the Old Testament prophets revealed the gospel they did not always grasp all of its implications (1 Pet. 1:10-12; cf. Rom. 1:2). The commandment of God in view is probably the expression of God's will.
16:27 As the only God, He is the God of both Jews and Gentiles (cf. 3:29-30). As the wise God, He is the author of the plan of salvation for all mankind that Paul had expounded (cf. 11:33). God is worthy of all glory because of who He is and what He has done. Our access to Him is through His Son, Jesus Christ.
This doxology is similar to the others in 8:31-39 and 11:33-36.