Specifically Eliphaz accused Job of speaking irreverently (vv. 1-6) and of pretending to be wiser and purer than he was (vv. 7-16). For a second time one of his friends said Job was full of hot air (vv. 2-3; cf. 8:2). The east wind (v. 2) was the dreaded sirocco that blew destruction in from the Arabian desert. Eliphaz judged that Job's iniquity (better than "guilt,"v. 5) caused him to speak as he did.
Eliphaz felt insulted that Job, a younger man, had rejected the wisdom of his older friends. This was an act of disrespect on Job's part, and Eliphaz interpreted it as a claim to superior wisdom. Job had made no such claim, however; he only said he had equal intelligence (12:3; 13:2). He did not claim to know why he was suffering as he was, only that his friends' explanation was wrong. Eliphaz interpreted Job's prayers of frustration to God as rebellion against God (vv. 12-13), which they were not. We need to be careful to avoid this error in our ministries too. Eliphaz was correct in judging all people corrupt sinners (v. 14), but he was wrong to conclude that Job was suffering because he was rebelling against God.