God now turned the tables on His people and called on them to awake (cf. v. 1). They needed to wake up to the fact that He would comfort them and punish their oppressors (cf. 40:2; Lam. 1-2). The fact that the Babylonian captivity continues to lie unmentioned specifically in the text strengthens the impression that God had more than that historic deliverance in view in what He promised. A greater future redemption is also in view, namely, the one that the Servant would affect.
51:17 Jerusalem had drunk a powerful liquid at the hand of her God. He had given her punishment to drink for her sins (cf. Mark 10:38). She now lay in a state of stupor but needed to arise because the Lord had a future for her.
51:18 She was unable to stand up and walk on her own so devastating had been the effects of the Lord's judgment of her. Moreover, she had no children (inhabitants) to help her go home.
51:19 Widowhood and childlessness had befallen Israel (cf. 47:9), and there were none to mourn for her. Furthermore, devastation, destruction, famine, and the sword had overtaken her. Since she deserved her punishment, the Lord could not comfort her as He could have if she had been an innocent victim.
51:20 The children were just as helpless as the mother.554They lay at major intersections of the city as exhausted as an antelope (oryx) caught in a net by its hunters. They too had suffered the wrath and rebuke of their God (cf. vv. 2, 17).
51:21 "Therefore"marks the transition from peril to promise. Isaiah appealed to afflicted Israel to listen to God's message. The Israelites had suffered the effects of intoxication, not from drinking real wine but the wrath of God (v. 20).
"Unlike Babylon, who sees herself as voluptuous (47:8), Zion knows herself as afflicted. But the same God speaks to both, telling Babylon to go down into the dust, and telling Zion to arise from the dust (52:2). Babylon thought herself independent and self-existent (47:10), but Zion believes the very opposite about herself: she is a helpless victim who can do nothing about her situation (40:27; 49:14). All this could be changed; if she would only listen to the voice of God (through the Servant, 50:10), she could stand in quiet confidence."555
51:22 The God offering Israel a comforting promise was her master, Yahweh, the God of the covenant, the God who had taken her to Himself, who consistently defends His people. He promised that the Israelites would never again experience the outpouring of His wrath as they had. Obviously the Jews have experienced worse persecution in recent history than they did during the Babylonian exile: the German holocaust, the Russian pogroms, etc. And they will undergo the worst trials of their history in the Tribulation (cf. Jer. 30:4-7). I take it that God meant that He would not punish them as He had because He would provide the Servant to drink the cup of His wrath for His people. They would not have to suffer in the future as they had in the past because God would provide a Savior who would suffer in their place. That the Jews have suffered terribly and will yet do so is because they have rejected the Savior that God provided.
51:23 Instead, God would give Israel's enemies His cup of wrath to drink. They had walked all over Israel, but that would end. The figure of walking on the backs of enemies stresses the victor's desire to humiliate the captives, not to slay them (cf. Josh. 10:24).
To summarize God's plans for Israel as revealed in Isaiah, unless she repented she would experience His judgment. God would use surrounding nations to punish His people. After this punishment, God would restore Israel and punish her oppressors.
(NT only) to listen to the NET Bible 
