5:16 This is one of approximately 70 New Testament commands to rejoice. This volitional choice is extremely important for the Christian. We can always rejoice if we remember what God has given us in Christ.
5:17 Greek writers used the adverb translated "without ceasing"to describe a hacking cough. Paul did not expect his readers to be in prayer every minute but to continue praying whenever possible.
"Not surprisingly Paul wished his converts to be people of prayer. He himself was devoted to prayer as a fundamental activity in his life (cf. 1:2b; 2 Thes. 1:11; Rom. 1:10; Col. 1:3, 9). In several of his letters he instructs his readers to devote themselves to prayer (cf. 5:25; 2 Thes. 3:1; Rom. 12:12; Phil. 4:6; Col. 4:2, 3)."129
5:18 We need to give thanks about everything knowing that God is working all things together for good for His people who love Him (Rom. 8:28). Paul said all of these commands are definitely God's will for every believer.